Efficient spectral editing at 7 T: GABA detection with MEGA-sLASER
نویسندگان
چکیده
منابع مشابه
GABA editing at 3T with Macromolecule Suppression: MEGA-SPECIAL
Introduction. One commonly used method for in-vivo magnetic resonance spectroscopy (MRS) detection of γ-aminobutyric acid (GABA) is the MEGA-PRESS technique [1], which enables direct observation of the GABA resonance at 3.02 ppm. Unfortunately, direct quantification of GABA using MEGA-PRESS is complicated by co-editing of macromolecule (MM) signals, which also resonate at 3.02 ppm [2]. Two meth...
متن کاملDirect in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla.
Spectral editing of the GABA spin system is hampered by coediting of macromolecule (MM) coherences. To reduce contamination arising from MMs in spectra edited for GABA, the highest field strength currently available for human experimentation (7 Tesla) and MEGA-based editing were used. Despite judicious choice of experimental parameters, MM contamination was found to arise from field drifts. Whe...
متن کاملArtefact minimized spectral editing at 7T: quick and accurate in-vivo detection of GABA
Introduction: Spectral editing techniques are used in MRS to improve the detection of low concentrated metabolites like GABA [1], of which signals are overlapped with resonances of other highly concentrated compounds, such as Creatine and macromolecules. However, these methods rely on subtraction of two in vivo MR spectra and, therefore, are prone to artefacts. MRS at high field benefits from h...
متن کاملDetection of Glutamate Alterations in the Human Brain Using 1H-MRS: Comparison of STEAM and sLASER at 7 T
PURPOSE To assess reproducibility of glutamate measurement in the human brain by two short echo time (TE) 1H-MRS sequences [stimulated echo acquisition mode (STEAM) and semi-localized by adiabatic selective refocusing (sLASER)] at 7 T. Reliable assessment of glutamate is important when studying a variety of neurological and neuropsychiatric disorders. At 7 T, the glutamate signal can be separat...
متن کاملGABA editing with macromolecule suppression using an improved MEGA-SPECIAL sequence.
PURPOSE The most common γ-aminobutyric-acid (GABA) editing approach, MEGA-PRESS, uses J-editing to measure GABA distinct from larger overlapping metabolites, but suffers contamination from coedited macromolecules (MMs) comprising 40 to 60% of the observed signal. MEGA-SPECIAL is an alternative method with better MM suppression, but is not widely used primarily because of its relatively poor spa...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2011
ISSN: 0740-3194
DOI: 10.1002/mrm.24131